The first time you boot with the Qio connected, the screen will stay blue for up to 6 minutes while the Mac is configuring the Qio slot space. Please be patient. Subsequent boots should be normal. Note that you must install the Qio software before connecting the Qio.
Sonnet measured read performance for three manufacturers' 600X (90MB/sec) CF cards in the Qio, connected to a MacBook Pro:
Lexar Professional 600X...86MB/sec
SanDisk Extreme Pro........61MB/sec