If you purchased your Qio before November 2011, you will need to update internal Qio ROMs to allow Windows to enable hot plug. This updater needs to be run from a Macintosh.
Some CF cards are seen as non-removable disks. Ejecting these cards will cause the whole Qio to eject. Restart the computer to restore functionality to the Qio and do not use "Eject" to remove CF cards.