There is a very limited resource in PCI I/O space in PCs. There is not enough I/O space for the Compact Flash drivers to start. Often this can be fixed by moving the Qio PCIe expander to a different slot.
Some CF cards are seen as non-removable disks. Ejecting these cards will cause the whole Qio to eject. Restart the computer to restore functionality to the Qio and do not use "Eject" to remove CF cards.