Go into device manager and "Scan for new Devices" to see an insertion or ejection. \f1 The CF cards use a hard disk IDE driver that does not expect hot plugging. Sonnet is developing an update that will allow hot plug.
The Qio BIOS software is not running and it must run to re-arrange the PCI busses. Because some PC's BIOS's do not allocate space for empty PCI slots, you may need to boot your PC with a card installed in one of the slots in the Qio. You can verify that the Qio BIOS software is loading by checking to see the Sonnet banner in the BIOS startup.