The Qio BIOS software is not running and it must run to re-arrange the PCI busses. Because some PC's BIOS's do not allocate space for empty PCI slots, you may need to boot your PC with a card installed in one of the slots in the Qio. You can verify that the Qio BIOS software is loading by checking to see the Sonnet banner in the BIOS startup.
Some CF cards are seen as non-removable disks. Ejecting these cards will cause the whole Qio to eject. Restart the computer to restore functionality to the Qio and do not use "Eject" to remove CF cards.