Some CF cards are seen as non-removable disks. Ejecting these cards will cause the whole Qio to eject. Restart the computer to restore functionality to the Qio and do not use "Eject" to remove CF cards.
This is a Microsoft Windows driver bug with some 64GB CF cards. Sonnet is working with Microsoft to resolve this issue. (64GB and 128GB CF cards work fine with Qio and Qio-CF in OS X.)
A partial list of cards Sonnet has tested:
Patriot Pro CF 266x 64GB/128GB card is recognized under Windows
Lexar Pro 1000x UDMA 7 64GB/128GB card reports itself as 32GB
SanDisk Extreme Pro UDMA 6 64GB/128GB card reports itself as 32GB