If you purchased your Qio before November 2011, you will need to update internal Qio ROMs to allow Windows to enable hot plug. This updater needs to be run from a Macintosh.
Some CF cards are seen as non-removable disks. Ejecting these cards will cause the whole Qio to eject. Restart the computer to restore functionality to the Qio and do not use "Eject" to remove CF cards.
You need to download and install the Sony SxS UDF Driver, available here http://pro.sony.com/bbsc/ssr/cat-recmedia/resource.downloads.bbsccms-assets-mkt-recmedia-downloads-upgrades.shtml